My experience on other distros was that upgrading in place a system that deviated too much from “stock” would wreck the install. I would personally play it safe and backup my home folder and do a fresh install.
Just don’t forget to test your backup before formatting your drive!
Kinoite is much more than that: it is an atomic and immutable spin of Fedora KDE. This has big implications but the gist of it is that:
You can roll back to any previous version if anything breaks
The base system cannot be modified
If you need to install RPM packages, you do that by adding “layers” on top of the base system, and these can be removed if needed to go back to a clean base system
You can switch from one spin to another by “rebasing”, but it is recommended that you remove any additional layer first and that you stick to the same desktop environment