There are differences. Most modern apps use .NET Core, which in itself is cross platform. Most of the time, they use a UI framework that is be cross platform as well (AvaloniaUI).
Of course newer apps and older apps made with .Net-Framework that may use Windows specific libraries (eg. System.Windows.Forms, System.Drawing) and lose their cross platform compatibility. They might work with Wine.
There are differences. Most modern apps use .NET Core, which in itself is cross platform. Most of the time, they use a UI framework that is be cross platform as well (AvaloniaUI).
Of course newer apps and older apps made with .Net-Framework that may use Windows specific libraries (eg. System.Windows.Forms, System.Drawing) and lose their cross platform compatibility. They might work with Wine.